Tagged: Thrombosis-Chip

Organ‐on‐Chip Recapitulates Thrombosis Induced by an anti‐CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems

Published in: Clinical Pharmacology & Therapeutics Clinical development of Hu5c8, a monoclonal antibody against CD40L intended for treatment of autoimmune disorders, was terminated due to unexpected thrombotic complications. These life‐threatening side‐effects were not discovered during preclinical testing due to the lack of predictive models. In the present study, we describe the development of a microengineered… Read more »

Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium

Published in: Biomed Microdevices The vascular endothelium and shear stress are critical determinants of physiological hemostasis and platelet function in vivo, yet current diagnostic and monitoring devices do not fully incorporate endothelial function under flow in their assess- ment and, therefore, they can be unreliable and inaccurate. It is challenging to include the endothelium in assays… Read more »