A Novel Microphysiological Colon Platform to Decipher Mechanisms Driving Human Intestinal Permeability

The limited availability of organoid systems that mimic the molecular signatures and architecture of human intestinal epithelium has been an impediment to allowing them to…

A human-Airway-on-a-Chip for the Rapid Identification of Candidate Antiviral Therapeutics and Prophylactics

Rapid assays for assessing candidate drugs typically involve in vitro screens and cell lines that do not recapitulate human physiology at the tissue and organ…

Effects of Human Milk Oligosaccharides on the Adult Gut Microbiota and Barrier Function

Here, we investigated the impact of HMOs on adult gut microbiota and gut barrier function using the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®),…

A Micro-Engineered Airway Lung-Chip Models Key Features of Viral-Induced Exacerbation of Asthma

Viral-induced exacerbation of asthma remain a major cause of hospitalization and mortality. New human relevant models of the airways are urgently needed to understand how…

Brain-Chip Neuroinflammation

Through the use of Organ-on-a-Chip technology, the human Brain-Chip has been established as a model that emulates in vivo-relevant features of neuroinflammation, an important aspect…

Brain-Chip Characterization

Despite the growing prevalence of neurodegenerative disease globally, effective disease-modifying therapies remain largely out of reach, partially due to a lack of robust preclinical models…

Cytokine-Mediated Inflammation in the Colon Intestine-Chip

Learn how the Colon Intestine-Chip can be used to study mechanisms of cytokine-mediated barrier inflammation in atime-, concentration-, and donor-dependent manner, as well as be…

Duodenum Intestine-Chip for Modeling Human Physiology

In this technical note, we review how our Chip-S1® Stretchable Chip can be used to create a comprehensive recapitulation of the human duodenum.

Assessing the Safety Liability of T Cell Bispecific (TCB) Antibodies Using Organs-on-Chips Technology

T-cell bispecific antibodies (TCBs) are a promising class of immunotherapeutic agents that promote tumor cell killing by physical crosslinking of effector T-cells to target expressing…

Developing a Human Liver-Chip Model for Alcoholic Steatosis

Emulate is developing a model for studying alcoholic steatosis using the Human Liver-Chip to induce cytotoxic levels of lipid accumulation by treating with increasing concentrations…

A Human Proximal Tubule Kidney-Chip for Accelerated Therapeutic Development

Drug-induced nephrotoxicity accounts for a majority of acute kidney injury (AKI) cases and is a primary cause of clinical attrition for lead therapeutic candidates.

Liver-Chip: A Model for Understanding Diet-Induced Liver Disease and Drug Efficacy Assessment

Lung-Chip—Accelerating Study of Viral Infection and Therapeutics

Infectious diseases, such as COVID-19, are challenging to study in animal models due to species differences, and conventional 2D cell-based systems lack the complexity to…

Brain-Chip: A Human Cell-Based Model for Studying Neuroinflammation

In this webinar, we present the Emulate Brain-Chip, the most comprehensive commercially available model of the human neurovascular unit.

Utilizing the Colon Intestine-Chip to Investigate Mechanisms of Gastrointestinal Disease

In this webinar, experts from Emulate and The Johns Hopkins University School of Medicine display their studies and clear data on how the Colon Intestine-Chip…

Colon Intestine-Chip Webinar

In this breakout session from our March 2021 virtual event, ‘Human Biology: An Exploration of Organs-on-Chips,’ we give an overview of our Colon Intestine-Chip and…