Resource LibraryFILTER BY Applications View All ApplicationsADME – ToxDrug Delivery & Gene TherapyImmune Cell RecruitmentImmunologyInfectious DiseaseMicrobiomeNeuroscienceFILTER BY Products View All ProductsBrain-ChipColon Intestine-ChipDuodenum Intestine-ChipKidney-ChipLiver-ChipLung-ChipOrb-HM1Zoë-CM1Zoë-CM2FILTER BY Resource Types View All Resource TypesApplication & Technical NotesData SheetsPostersPublicationsUser GuidesWebinarsWebinarsTherapeutic Antibody Pharmacology Applications on the Human Liver-ChipIn this on-demand webinar, Dr. Candarlioglu discusses the Emulate Liver-Chip and how it allows scientists to model antibody clearance in a human-relevant in vitro model.Cancer-on-a-chip: Modeling Colorectal Cancer ProgressionIn this on-demand webinar, Dr. Mumenthaler discusses recent advancements made through combining Organ-Chip models with high content imaging and mass spectrometry-based metabolomics to improve our understanding…Predicting Hepatotoxicity with the Liver-ChipIn this webinar, Dr. Jonathan Sexton presents an evaluation of iPSC-derived human liver organoids (HLOs) that spontaneously produce autologous hepatocytes In this webinar, Dr. Jonathan…Predictive Toxicology: Organ-Chips Demonstrate Superior Performance to Animal Models and SpheroidsHuman organ-on-a-chip (Organ-Chip) technology has the potential to disrupt preclinical drug discovery, as it has been shown to recapitulate organ-level pathophysiology and clinical responsesSee MoreApplication & Technical NotesModeling Inflammation-Specific Immune Cell Recruitment in the Colon Intestine-ChipThis application uses the Colon Intestine-Chip to model the progression of IBD driven by immune cells more completely than previous models.Brain-Chip NeuroinflammationThrough the use of Organ-on-a-Chip technology, the human Brain-Chip has been established as a model that emulates in vivo-relevant features of neuroinflammation, an important aspect…Brain-Chip CharacterizationDespite the growing prevalence of neurodegenerative disease globally, effective disease-modifying therapies remain largely out of reach, partially due to a lack of robust preclinical models…Cytokine-Mediated Inflammation in the Colon Intestine-ChipLearn how the Colon Intestine-Chip can be used to study mechanisms of cytokine-mediated barrier inflammation in atime-, concentration-, and donor-dependent manner, as well as be…See MorePostersAdvanced Modeling of Inflammatory Immune Cell Recruitment and Response on Human Colon Intestine-Chip for IBD Therapeutic DevelopmentSee how the Colon Intestine-Chip has been used to model colon- and inflammation-specific immune recruitment and assess IBD drug candidate effect.Assessing the Safety Liability of T Cell Bispecific (TCB) Antibodies Using Organs-on-Chips TechnologyT-cell bispecific antibodies (TCBs) are a promising class of immunotherapeutic agents that promote tumor cell killing by physical crosslinking of effector T-cells to target expressing…Developing a Human Liver-Chip Model for Alcoholic SteatosisEmulate is developing a model for studying alcoholic steatosis using the Human Liver-Chip to induce cytotoxic levels of lipid accumulation by treating with increasing concentrations…A Human Proximal Tubule Kidney-Chip for Accelerated Therapeutic DevelopmentDrug-induced nephrotoxicity accounts for a majority of acute kidney injury (AKI) cases and is a primary cause of clinical attrition for lead therapeutic candidates.See MoreUser GuidesOrb-HM1 User GuideThe Orb-HM1® Hub Module connects to standard lab outputs and provides gas, power, and stretch to up to four Zoë® Culture Modules.Zoë-CM1™ User GuideThis user guide has essential instructions for how to safely and effectively operate your Zoë-CM1.Data Privacy & Security for Emulate Software ApplicationsZoë sustains the life of cells within Emulate Organ-Chips by automating the precise microphysiological conditions needed to culture up to 12 chips. As an open…Zoë-CM2™ User GuideZoë sustains the life of cells within Emulate Organ-Chips by automating the precise microphysiological conditions needed to culture up to 12 chips. As an open…Data SheetsLiver Bio-Kit Data SheetThe Liver Bio-Kit includes the essential components needed to create the Liver-Chip—including Emulate qualified cells—and is available in multiple sizes to meet various study needs.Zoë-CM2™ Culture Module Data SheetZoë sustains the life of cells within Emulate Organ-Chips by automating the precise microphysiological conditions needed to culture up to 12 chips. As an open…Brain Bio-Kit Data SheetThe Brain Bio-Kit includes the essential components needed to create the Brain-Chip—including Emulate qualified cells—and is available in multiple sizes to meet various study needs.PublicationsThe Future of Uncertainty Factors With In Vitro StudiesNew approach methodologies (NAMs), including in vitro toxicology methods such as human cells from simple cell cultures to 3D and organ-on-a-chip models of human lung,…Qualifying a human Liver-Chip for predictive toxicology: Performance assessment and economic implicationsA computational economic value analysis suggests that with this performance the Liver-Chip could generate $3 billion annually for the pharmaceutical industry due to increased R&D…Modeling alpha-synuclein pathology in a human Brain-Chip to assess blood-brain barrier disruptionHere we leverage the Organ-on-a-Chip technology to engineer a human Brain-Chip as a αSyn fibril-induced model of Parkinson’s disease.Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodiesRead how the Lung-Chip and Intestine-Chip reproduce and predict target-dependent TCB safety liabilities, based on sensitivity to key determinants thereof, such as target expression and…See More
