Resource LibraryFILTER BY Applications View All ApplicationsADME – ToxDrug Delivery & Gene TherapyImmunologyInfectious DiseaseMicrobiomeNeuroscienceFILTER BY Products View All ProductsBrain-ChipColon Intestine-ChipDuodenum Intestine-ChipKidney-ChipLiver-ChipLung-ChipZoë-CM2FILTER BY Resource Types View All Resource TypesApplication & Technical NotesData SheetsPostersPublicationsUser GuidesWebinarsWebinarsPredictive Toxicology: Organ-Chips Demonstrate Superior Performance to Animal Models and SpheroidsHuman organ-on-a-chip (Organ-Chip) technology has the potential to disrupt preclinical drug discovery, as it has been shown to recapitulate organ-level pathophysiology and clinical responsesModeling Virus Evolution and Rapid Drug Repurposing with a Human Airway Lung-ChipDue to the rapid evolution of viruses, including influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), researchers are struggling to match pace in developing…Microengineered Human Brain-Chip for Disease Modeling ApplicationsHere we present a human Brain-Chip system engineered to recapitulate critical aspects of the complex neurovascular unit. Our human organotypic microphysiological system includes endothelial cells,…Lung-Chip—Accelerating Study of Viral Infection and TherapeuticsInfectious diseases, such as COVID-19, are challenging to study in animal models due to species differences, and conventional 2D cell-based systems lack the complexity to…See MorePublicationsThe Future of Uncertainty Factors With In Vitro StudiesNew approach methodologies (NAMs), including in vitro toxicology methods such as human cells from simple cell cultures to 3D and organ-on-a-chip models of human lung,…Qualifying a human Liver-Chip for predictive toxicology: Performance assessment and economic implicationsA computational economic value analysis suggests that with this performance the Liver-Chip could generate $3 billion annually for the pharmaceutical industry due to increased R&D…Modeling alpha-synuclein pathology in a human Brain-Chip to assess blood-brain barrier disruptionHere we leverage the Organ-on-a-Chip technology to engineer a human Brain-Chip as a αSyn fibril-induced model of Parkinson’s disease.Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodiesRead how the Lung-Chip and Intestine-Chip reproduce and predict target-dependent TCB safety liabilities, based on sensitivity to key determinants thereof, such as target expression and…See MoreUser GuidesData Privacy & Security for Emulate Software ApplicationsZoë sustains the life of cells within Emulate Organ-Chips by automating the precise microphysiological conditions needed to culture up to 12 chips. As an open…Zoë Manager User GuideZoë sustains the life of cells within Emulate Organ-Chips by automating the precise microphysiological conditions needed to culture up to 12 chips. As an open…Zoë-CM2™ User GuideZoë sustains the life of cells within Emulate Organ-Chips by automating the precise microphysiological conditions needed to culture up to 12 chips. As an open…Data SheetsZoë-CM2™ Culture Module Data SheetZoë sustains the life of cells within Emulate Organ-Chips by automating the precise microphysiological conditions needed to culture up to 12 chips. As an open…Brain Bio-Kit Data SheetThe Brain Bio-Kit includes the essential components needed to create the Brain-Chip—including Emulate qualified cells—and is available in multiple sizes to meet various study needs.Application & Technical NotesBrain-Chip NeuroinflammationThrough the use of Organ-on-a-Chip technology, the human Brain-Chip has been established as a model that emulates in vivo-relevant features of neuroinflammation, an important aspect…Brain-Chip CharacterizationDespite the growing prevalence of neurodegenerative disease globally, effective disease-modifying therapies remain largely out of reach, partially due to a lack of robust preclinical models…Cytokine-Mediated Inflammation in the Colon Intestine-ChipLearn how the Colon Intestine-Chip can be used to study mechanisms of cytokine-mediated barrier inflammation in atime-, concentration-, and donor-dependent manner, as well as be…Duodenum Intestine-Chip for Modeling Human PhysiologyIn this technical note, we review how our Chip-S1® Stretchable Chip can be used to create a comprehensive recapitulation of the human duodenum.See MorePostersAssessing the Safety Liability of T Cell Bispecific (TCB) Antibodies Using Organs-on-Chips TechnologyT-cell bispecific antibodies (TCBs) are a promising class of immunotherapeutic agents that promote tumor cell killing by physical crosslinking of effector T-cells to target expressing…Developing a Human Liver-Chip Model for Alcoholic SteatosisEmulate is developing a model for studying alcoholic steatosis using the Human Liver-Chip to induce cytotoxic levels of lipid accumulation by treating with increasing concentrations…A Human Proximal Tubule Kidney-Chip for Accelerated Therapeutic DevelopmentDrug-induced nephrotoxicity accounts for a majority of acute kidney injury (AKI) cases and is a primary cause of clinical attrition for lead therapeutic candidates.Liver-Chip: A Model for Understanding Diet-Induced Liver Disease and Drug Efficacy AssessmentSee More
