Resource LibraryFILTER BY Applications View All ApplicationsADME – ToxDrug Delivery & Gene TherapyImmunologyInfectious DiseaseMicrobiomeNeuroscienceFILTER BY Products View All ProductsBrain-ChipColon Intestine-ChipDuodenum Intestine-ChipKidney-ChipLiver-ChipLung-ChipFILTER BY Resource Types View All Resource TypesApplication & Technical NotesPostersPublicationsWebinarsPublicationsHuman immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodiesThe limited availability of organoid systems that mimic the molecular signatures and architecture of human intestinal epithelium has been an impediment to allowing them to…A Novel Microphysiological Colon Platform to Decipher Mechanisms Driving Human Intestinal PermeabilityThe limited availability of organoid systems that mimic the molecular signatures and architecture of human intestinal epithelium has been an impediment to allowing them to…A human-Airway-on-a-Chip for the Rapid Identification of Candidate Antiviral Therapeutics and ProphylacticsRapid assays for assessing candidate drugs typically involve in vitro screens and cell lines that do not recapitulate human physiology at the tissue and organ…Effects of Human Milk Oligosaccharides on the Adult Gut Microbiota and Barrier FunctionHere, we investigated the impact of HMOs on adult gut microbiota and gut barrier function using the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®),…See MoreApplication & Technical NotesBrain-Chip NeuroinflammationThrough the use of Organ-on-a-Chip technology, the human Brain-Chip has been established as a model that emulates in vivo-relevant features of neuroinflammation, an important aspect…Brain-Chip CharacterizationDespite the growing prevalence of neurodegenerative disease globally, effective disease-modifying therapies remain largely out of reach, partially due to a lack of robust preclinical models…Cytokine-Mediated Inflammation in the Colon Intestine-ChipLearn how the Colon Intestine-Chip can be used to study mechanisms of cytokine-mediated barrier inflammation in atime-, concentration-, and donor-dependent manner, as well as be…Duodenum Intestine-Chip for Modeling Human PhysiologyIn this technical note, we review how our Chip-S1® Stretchable Chip can be used to create a comprehensive recapitulation of the human duodenum.See MorePostersAssessing the Safety Liability of T Cell Bispecific (TCB) Antibodies Using Organs-on-Chips TechnologyT-cell bispecific antibodies (TCBs) are a promising class of immunotherapeutic agents that promote tumor cell killing by physical crosslinking of effector T-cells to target expressing…Developing a Human Liver-Chip Model for Alcoholic SteatosisEmulate is developing a model for studying alcoholic steatosis using the Human Liver-Chip to induce cytotoxic levels of lipid accumulation by treating with increasing concentrations…A Human Proximal Tubule Kidney-Chip for Accelerated Therapeutic DevelopmentDrug-induced nephrotoxicity accounts for a majority of acute kidney injury (AKI) cases and is a primary cause of clinical attrition for lead therapeutic candidates.Liver-Chip: A Model for Understanding Diet-Induced Liver Disease and Drug Efficacy AssessmentSee MoreWebinarsLung-Chip—Accelerating Study of Viral Infection and TherapeuticsInfectious diseases, such as COVID-19, are challenging to study in animal models due to species differences, and conventional 2D cell-based systems lack the complexity to…Brain-Chip: A Human Cell-Based Model for Studying NeuroinflammationIn this webinar, we present the Emulate Brain-Chip, the most comprehensive commercially available model of the human neurovascular unit.Utilizing the Colon Intestine-Chip to Investigate Mechanisms of Gastrointestinal DiseaseIn this webinar, experts from Emulate and The Johns Hopkins University School of Medicine display their studies and clear data on how the Colon Intestine-Chip…Colon Intestine-Chip WebinarIn this breakout session from our March 2021 virtual event, ‘Human Biology: An Exploration of Organs-on-Chips,’ we give an overview of our Colon Intestine-Chip and…See More
