CAR T-Cell Recruitment and Killing can be Evaluated on an Organ-Chip Model System

Abstract

Chimeric antigen receptor (CAR) T-cell therapy holds great promise for treating solid tumors. However, there are significant challenges in developing an effective CAR T cell solid tumor therapy due to a lack of human-relevant models that adequately capture mechanisms of CAR T cell recruitment—a critical rate-limiting step in CAR T cell efficacy that is often overlooked.

View this poster, presented at IMMUNOLOGY2024, to learn how Emulate researchers developed a novel system for investigating both the recruitment and killing capacity of CAR T cells in an Organ-Chip model.