Evaluate small molecule ADME and mechanistic toxicity with clinically relevant results in drug discovery and development.
Model tumor metastasis and immune system interaction in a more accurate tumor microenvironment to accelerate development of novel immuno-oncology therapies.
Explore the contribution of the tissue-level inflammatory response and immune cell recruitment in the initiation and progression of disease.
Investigate mechanisms of human viral and bacterial infection, including SARS-CoV-2, and evaluate efficacy of candidate drugs to prevent or treat infection.
Gain mechanistic insights into microbe-host interaction and function in the complex intestine-specific microenvironment.
Examine disease mechanisms and neuroinflammation, as well as evaluate the safety, efficacy, and blood-brain barrier penetration of novel therapeutics.