3 Instruments in 1

AVA Emulation System

A powerful yet compact benchtop unit

AVA is a self-contained instrument that cultures, incubates, and images up to 96 independent Organ-Chip samples in a single run, delivering in vivo fidelity at scale.

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AVA EMulation System

Expanded experimental power

AVA is a self-contained instrument that cultures, incubates, and images up to 96 independent Organ-Chip samples in a single run, delivering in vivo fidelity at scale.

AVA EMulation System

Intelligent Imaging – Automated

Set it and forget it. Automated imaging eliminates the in-lab, hands-on work of monitoring cells. Customized imaging programs ensure that you capture the most valuable images throughout your study, without having to step foot in the lab.

AVA EMulation System

Small Footprint, Big Impact

As a free-standing benchtop unit, AVA frees up space in your cell culture incubators, and its built-in microscope lets you track tissue morphology and biomarker expression without interrupting culture conditions for more consistent experiments.

Chip-Array™ Organ-Chip Consumable

A revolutionary 12-in-1 Organ-Chip design empowering high-throughput studies

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Chip-Array

12 Chips in 1

At the heart of AVA is Chip-Array, a revolutionary consumable that combines 12 individual Organ-Chip samples (“Emulations”) into the compact footprint of a standard 96-well plate with multichannel pipette compatibility.

AVA can culture up to 8 Chip-Arrays at a time for a total of 96 Emulations in a single experiment, driving an 8-fold scale-up in throughput without increasing labor requirements.

CHIP-ARRAY

Streamlined Workflows

Featuring the same footprint as a 96-well plate, the SBS‑compatible format of Chip-Array enables seamless integration with multichannel pipettes and automated liquid handlers, accelerating throughput while maintaining the physiological fidelity that defines Organ‑on-a-Chip technology.

Chip-Array

Versatile Biological Modeling Capabilities

With a classic two-channel architecture at the heart of each Emulation in Chip-Array, users can create tissue-tissue interfaces with independent perfusion of the top and bottom channels. The open nature of Chip-Array makes it compatible with practically any type of human or animal cell, including primary cells, dissociated organoids, induced pluripotent stem cells (iPSCs), and immortalized cell lines.

Workflow improvements at every stage

At the heart of AVA is Chip-Array, a revolutionary consumable that combines 12 individual Organ-Chip samples (“Emulations”) into the compact footprint of a standard 96-well plate with multichannel pipette compatibility.

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Efficient Workflows

Stress-free experiment prep

Intuitive experiment planning tools such as pre-loaded templates, automated schedulers, and plate-mapping functions make it easy to design and execute high-throughput studies, while the ability to use multichannel pipettes creates efficient seeding workflows.

Efficient Workflows

Accelerated Analysis

Robust data management systems and compatibility with downstream analysis tools make it easy to transform your data into actionable insights.

Multi-modal data generation with AI-ready datasets

A typical 7-day experiment can generate >30,000 time-stamped data points from daily imaging and effluent assays, with post-takedown omics pushing the total into the millions—providing a rich, multi-modal foundation to feed machine-learning pipelines for target discovery, lead optimization, and safety prediction.

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Analysis

Effluent Based Assays

Sampling the media effluent that flows out of an Organ-Chip at multiple time-points turns the chip into a “living biopsy,” letting you watch the biology unfold rather than taking a single snapshot at the end.

With AVA, users can easily generate 1300 data points per day from effluent-based assays. Over the course of a 7-day experiment, that adds up to over 9,000 time-stamped events, enabling users to build a high-resolution kinetic profile of secreted cytokines, metabolites, or drug and metabolite concentrations.

Analysis

Fixed cell imaging

Deep post-run interrogation. After the experiment, chips can be fixed and subjected to high-resolution quantitative fluorescence microscopy to map protein expression, pathway activation, or spatial co-localization at single-cell detail. These endpoint images complement the live cell imaging data, closing the loop between early functional changes and final molecular outcomes.

Analysis

Multi-omic insights

Organ-Chip effluent can be used for a wide range of downstream assays, including ELISA, LC-MS/MS, RNA/DNA-seq of of cells or extracellular vesicles, proteomics, metabolomics, and more. The diversity of these assays lets users mine multiple layers of biology from the same experiment.

Analysis

Organ-Chips + AI

AI-ready datasets. The combination of mid-experiment data streams and high-content endpoint analyses yields rich, multimodal input for machine-learning models that predict potency, off-target effects, and structure-activity relationships with far greater confidence than static well-plate assays or non-human relevant animal models.