One way the immune system responds to signs of danger, damage, and infection in the human body is through recruiting circulatory immune cells from the blood stream. However, this process can become dysfunctional, leading to vicious cycles of excessive immune cell recruitment and pro-inflammatory responses. This dysregulated inflammation is behind 3 out of 5 deaths worldwide; as such, there is a pressing need for more effective therapeutics.
Organ-on-a-Chip technology gives researchers a more human-relevant window into the inner workings of inflammatory response. Read this eBook to learn more about inflammatory disease, the inherent challenges in trying to study it with conventional models, and how Organ-Chips allow scientists to gain deeper insights into inflammatory response and create better drug candidates.