Organ Model: Lymph Node
Application: Immunology (vaccine development)
Highlights
In this study, Organ-Chips were used to model the human immune response to intramuscular mRNA vaccines by combining a biomimetic muscle module with a microfluidic human lymphoid follicle chip (LF Chip). mRNA vaccines were administered into the muscle module containing human myoblasts and antigen-presenting cells (APCs), and the resulting APCs and soluble factors were transferred to the LF Chip to mimic lymphatic drainage, leading to antigen-specific antibody production and cytokine release. This platform enabled evaluation of both primary and recall immune responses, including neutralizing antibody generation and somatic hypermutation.
