Overview
Learn how our Duodenum Intestine-Chip can be applied to emulate the complex functions and physiology of the human intestine.
In this technical note, we review how our Chip-S1® Stretchable Chip can be used to create a comprehensive recapitulation of the human duodenum.
Key highlights:
- Co-culture model incorporates both organoid-derived primary epithelial cells and primary human intestinal microvascular endothelial cells (HIMECs)
- Flow and cyclic stretch recreate mechanical forces that improve cell morphology and function
- Organ-specific microenvironment results in transcriptomic profile closer to in vivo compared to organoids alone
- Potential applications include assessment of transporter activity and CYP450-mediated metabolism