Duodenum Intestine-Chip for Modeling Human Physiology

Overview

Learn how our Duodenum Intestine-Chip can be applied to emulate the complex functions and physiology of the human intestine.

In this technical note, we review how our Chip-S1® Stretchable Chip can be used to create a comprehensive recapitulation of the human duodenum.

Key highlights:

  • Co-culture model incorporates both organoid-derived primary epithelial cells and primary human intestinal microvascular endothelial cells (HIMECs)
  • Flow and cyclic stretch recreate mechanical forces that improve cell morphology and function
  • Organ-specific microenvironment results in transcriptomic profile closer to in vivo compared to organoids alone
  • Potential applications include assessment of transporter activity and CYP450-mediated metabolism