Custom Services
Let our team of Organ-Chip experts tailor applications to suit your needs.
Custom Services Overview
If your research needs don’t align with one of our standard service offerings, team up with our expert scientists to develop custom collaboration projects for your application of interest. Each of our Organ-Chip models and applications can be tailored to meet your research requirements. Additionally, we can source multiple donors for more robust insights. Let us know what you’re looking for, and our team will determine how we can help.
Examples of Custom Projects
T-Cell Engagement & Activation
In collaboration with Roche, the Emulate team used the Duodenum Intestine-Chip and Colon Intestine-Chip to assess on-target, off-tumor safety risk of T-cell bispecific antibodies (TCBs) applied directly to the epithelial channel. Roche brought Organ-Chips into their workflow because conventional preclinical models had failed to translate to humans. The two Intestine-Chip models effectively demonstrated regional and target affinity-dependent gastrointestinal toxicity in response to TCB treatment, recreated in vivo mechanisms of TCB-mediated toxicity, and identified a safer TCB candidate. Ultimately, this approach cleared the path for determining a safe therapeutic window.
Thrombosis
It is incredibly difficult to predict drug-induced thrombosis in humans using conventional preclinical models like cell cultures, which lack necessary complexity, or animals, which do not replicate human-specific responses. In a paper published in Clinical Pharmacology and Therapeutics, a team of researchers overcame these limitations by developing a Blood Vessel-Chip to assess the safety of Hu5c8, a drug candidate that caused unexpected thrombosis in clinical trials. Using this Organ-Chip model, they recreated the pro-thrombotic effects of Hu5c8 at clinically relevant drug concentrations for the first time in vitro, revealing the role of patient-specific biomarkers in assessing thrombotic response and opening the door for Organ-on-a-Chip technology to be used in biomarker identification and clinical trial patient stratification.
Bone Marrow
The Wyss Institute for Biologically Inspired Engineering needed to study the full cycle of drug-induced bone marrow injury and post-treatment recovery in response to chemotherapeutics and ionizing radiation—something that cannot be done effectively using conventional cell-based or animal models. So, they partnered with Emulate to design a Bone Marrow-Chip that could model human response to adverse stimuli as well as genetic abnormalities. Not only did the data show that this novel chip solved the issues in areas where conventional methods had failed them, they also seeded the chip with cells from a patient suffering a rare genetic disorder to successfully model key hematopoietic defects.
Metabolism
A study published in Science Translational Medicine showcases how species-specific versions of the Liver-Chip can be used to identify differences in drug metabolism and toxicity. The study revealed that CYP activities measured in co-culture human, rat, and dog chips over a 14-day period were comparable to—or even greater than—those exhibited by freshly isolated hepatocytes.
Industry-Leading Expertise
Meet the experts behind our services team and learn why we’re passionate about helping you succeed with Organ-Chips
