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Chip-R1 Rigid Chip: Improved Precision in ADME-Tox Testing

December 4, 2024
10:00 am — 10:50 am EST

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Synopsis

Discover a new standard in Organ-on-a-Chip technology with the Emulate Chip-R1™ Rigid Chip. This new Organ-Chip consumable is designed to minimize drug absorption for enhanced precision in drug toxicology, ADME, and efficacy studies. The Chip-R1 maintains the two-channel architecture of the Chip-S1® Stretchable Chip while incorporating several enhancements, including low-absorbing rigid materials, increased maximum shear stress in the vascular channel, a tissue-culture treated membrane for streamlined workflows, and a reduced chip membrane pore diameter. 

Join us on Wednesday, December 4th at 10AM EST (7AM PST / 3PM  GMT / 4PM CET) as our expert speakers dive into the advanced features of the Chip-R1 and share data from our Liver-Chip R1 application note, demonstrating how this consumable can be used to model the liver sinusoid and improve prediction of drug-induced liver injury (DILI). 

In this webinar, you will: 

  • Discover the advanced features of the Chip-R1, including its low-absorbing materials, pre-activated tissue culture membrane, and increased maximum vascular channel shear force. 
  • See how low-drug-absorbing materials reduce compound loss, enabling more precise toxicity and efficacy assessments for lipophilic small molecules. 
  • Explore the Liver-Chip R1’s robust liver functionality, including albumin production, metabolic activity, and immunofluorescence imaging of the four primary cell types of the human liver sinusoid. 
  • Learn how to leverage the Liver-Chip R1 for improved DILI detection, with comparative data highlighting the advantages of Liver-Chip R1 over Liver-Chip S1. 

Whether you’re focused on improving predictive toxicology, ADME experiments, or efficacy testing, this webinar will provide the insights you need to elevate your research. 

Register today and take the first step towards more precise, human-relevant data with the Chip-R1. 

Register

Speaker Spotlight

Luke Dimasi

Senior Director, Product Management, Emulate

Anthony Heng

Scientist II, Emulate