Application

Cell Therapy

Model the holistic journey of CAR T-cell therapy for solid tumors—from vascular administration to target cell killing

Your challenge

Cell therapy trafficking remains a critical rate-limiting step of cell therapy efficacy for solid tumors

While chimeric antigen receptor (CAR) T-cell therapy has shown success in treating hematological malignancies, successfully treating solid tumors remains a challenge.

To be effective against solid tumors, CAR T cells must first exit the vasculature at the tumor location, infiltrate deeply into the tumor, lock in with tumor-specific antigens, and finally kill the cancer cells. It’s a long, well-orchestrated journey that conventional cell-based models cannot capture due to their simplicity.

our solution

Model the holistic journey of solid tumor cell therapy

With the CAR T workflow for Emulate Organ-Chips, researchers can model the holistic journey of CAR T-cell therapy from blood vessel to target—including CAR T cell vascular administration, tumor inflammation-specific endothelial cell attachment and migration, and antigen-specific killing—in a vascularized cancer cell line model.

Schematic of the CAR T-cell therapy workflow.

This novel and flexible workflow allows for a more complete, human-relevant assessment of cell therapy recruitment and efficacy than alternatives, providing researchers with the ability to discover and evaluate CAR engineering and co-therapeutic approaches to improve cell therapy migration and efficacy against solid tumor targets. Download the application note to discover the workflow.

administer your CAR T-cell therapy On-chip to:

Quantify vascular attachment, recruitment, and killing in a single assay

Assess antigen-specific killing and degranulation

Investigate co-therapeutic strategies to enhance CAR T functionality

Adapt the workflow to study various target tumor cells, cell therapies, and co-therapeutics

Featured Resource

Application Note: Evaluating CAR T-Cell Therapy Vascular Recruitment, Trafficking & Killing Efficacy with Organ-on-a-Chip Technology

See the data

Products & Services

Whether in your lab or in ours, we offer the technology, workflows, and support you need to get started studying solid tumor cell therapy with Organ-Chips

Product Offerings

We offer the Organ-Chips, protocols, and support you need to get started in your lab—all powered by the Human Emulation System®

Let’s Talk
Basic research kit

Includes chips and reagents for use with customer cell sourcing.

protocol & Data Analysis tool

Protocol for CAR T-cell therapy administration and workflow adaptation, as well as a custom analysis tool for quantification of recruitment and killing.

User support

Expert scientific training and support—no matter your experience level with Organ-Chips.

Fee-for Service Offerings

Let our team of experts do the work for you.

Let’s talk
custom services

Our team will design and execute a cell therapy study to meet your needs using customer- or Emulate-sourced cells.

Related Resources

Evaluating CAR T-Cell Therapy Vascular Recruitment, Trafficking & Killing Efficacy with Organ-on-a-Chip Technology

Basic Research Kit: Chip-S1

Evaluating Solid Tumor CAR T Efficacy with Organ-on-a-Chip Technology

Basic Research Kit: Chip-S1

CAR T-Cell Recruitment and Killing can be Evaluated on an Organ-Chip Model System

Basic Research Kit: Chip-S1

Chip-S1 Basic Research Kit Data Sheet

Basic Research Kit: Chip-S1

Human Emulation System Brochure

Human Emulation System

Emulate Contract Research Services Brochure

Contract Research Services