REST and Stress Resistance in the Ageing Kidney

Organ Model: Kidney (Glomerulus mouse)

Application: Model Development

Abstract: CKD is associated with the loss of functional nephrons, leading to increased mechanical and metabolic stress in the remaining cells, particularly for cells constituting the filtration barrier, such as podocytes. The failure of podocytes to mount an adequate stress response can lead to further nephron loss and disease progression. However, the mechanisms that regulate this degenerative process in the kidney are unknown.