Proximal Tubule Kidney-Chip for Modeling Human Physiology

Overview

In the pharmaceutical industry, there is a need for more human-relevant preclinical models to improve translation to clinical trials. Organ-Chips can help address this need by recreating in vivo-relevant function in a more physiological microenvironment than conventional cell-based models. In this technical note, we review how our Chip-S1 can be used to create a comprehensive recapitulation of the proximal tubule

Key highlights:

  • Kidney-Chip emulates in vivo-like physiology by incorporating a co-culture of primary human kidney-specific epithelial and endothelial cells in a dynamic microenvironment.
  • Continuous perfusion of media ensures cells are exposed to sufficient amounts of test compounds, metabolites, or other stimulus factors
  • Cells can be fixed and imaged for further analysis or removed and processed for genomic studies
  • Potential applications include investigate of drug candidate toxicity as well as evaluation of transporter-mediated drug-drug interactions.