Inflammatory bowel disease (IBD)-specific immune cell recruitment and response can be modulated with anti-TNF-α therapies in the human Colon Intestine-Chip


Inflammatory bowel disease (IBD) is a complex inflammatory disease, for which few effective therapies exist. The goal of our current work was to show that:

  1. Such a complex, immune cell-driven pathogenesis could be captured on Emulate’s human Colon Intestine-Chips
  2. This could be used as a novel human-centric system to support IBD drug development including anti-TNF-α antibodies. We previously developed an advanced primary human vascularized Colon Intestine-Chip model and showed that it can recapitulate physiologic cell composition, morphology and barrier integrity.

The model described in this poster is advantageous in recapitulating in vivo inflammatory effector functions in that it supports immune cell trafficking under fluid flow conditions, uses primary cell co-culture, and provides a physiologically relevant peristaltic-like stretch.