Development and evaluation of a bovine lung-on-chip (bLOC) to study bovine respiratory diseases

Organ Model: Lung (bovine)

Application: Infectious Disease

Abstract: Current air-liquid interface (ALI) models of bovine proximal airways have their limitations. They do not simulate blood flow necessary to mimic systemic drug administration, and repeated sampling requires multiple, independent cultures. A bovine lung-on-chip (bLOC) would overcome these limitations, providing a convenient and cost-effective model for pharmacokinetic or pathogenicity studies.