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Society for Neuroscience – Global Connectome 2021

January 11, 2021 — January 13, 2021
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Synopsis

This brand-new, cross-cutting digital neuroscience event is designed to facilitate scientific exchange across the globe and across the field, providing scientists at all career stages, of all disciplines, with opportunities to learn, collaborate, and connect.

 

Speaker Spotlight

Iosif Pediaditakis, PhD

Associate Director of Scientific Research, Emulate

Abstract

Species differences in brain function and blood-brain barrier often preclude accurate extrapolation from animal models to human patients. There is an unmet need for human relevant systems that can recreate key aspects of brain physiology and pathophysiology of common diseases. We are developing a human Brain-Chip to model neuroinflammation, a hallmark of many neurodegenerative diseases, to enable studies on mechanistic aspects of neural pathology and disease progression. We provide evidence that this complex human Brain-Chip model can support co-culture and establishment of extensive interconnection between human iPSC-derived neurons and primary glia cells (astrocytes and microglia). Human iPSC-derived brain endothelial cells successfully maintained at the vascular channel of the Brain-Chip in the presence of fluidic shear stress, while exhibiting hallmark features of the human blood-brain barrier, such as development of specific tight junctions and minimal barrier permeability. Exposure to inflammatory triggers (e.g. TNF-α) or toxic protein oligomeric species (e.g. alpha-synuclein), resulted in neuronal death, glia activation, increased secretion of the corresponding proinflammatory cytokines, and a compromised barrier function. In summary, our current findings demonstrate the development of a human Brain-Chip that could support the development of models for the study of neuroinflammation and blood-brain barrier disfunction in neurological disorders.

About Emulate

Emulate Inc. is a privately held company that creates advanced in vitro models for understanding how diseases, medicines, chemicals, and foods affect human health. Our lab-ready Human Emulation System® includes three components: Zoë® Culture Module, Organ-Chips, and analytical software applications. The platform provides a window into the inner workings of human biology and disease—offering researchers a new technology designed to predict human response with greater precision and detail than conventional cell culture or animal-based experimental testing. Each of the Emulate proprietary Organ-Chip models—including the liver, intestine, and kidney—contains tiny hollow channels lined with tens of thousands of living human cells and tissues and is approximately the size of an AA battery. An Organ-Chip is a living, microengineered environment that recreates the natural physiology and mechanical forces that cells experience within the human body. Our founding team pioneered the Organs-on-Chips technology at the Wyss Institute for Biologically Inspired Engineering at Harvard University. Emulate holds the worldwide exclusive license from Harvard University to a robust and broad intellectual property portfolio for the Organs-on-Chips technology and related systems. For more information, please visit emulatebio.com.

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