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Brain Chip: A Human Cell-Based Model for Studying Neuro Inflammation

June 15, 2021
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Synopsis

To date, researching neurogenerative disease and developing effective therapeutics has been limited by the shortcomings of current models—static cell culture with limited cellular complexity and animal models that often fail to translate to human response. To develop more effective treatments, a more physiologically relevant brain model is needed. 

In this webinar, we present the Emulate Brain-Chip, the most comprehensive commercially available model of the human neurovascular unit that recreates key features of brain and blood-brain barrier physiology for studying neuroinflammation. 

Learn how you can use the Brain-Chip to: 

  • Create a more physiological brain model: Co-culture five key cell types in a highly-tunable model with low barrier permeability, high transcriptomic similarity to in vivo tissue, and demonstrated advantages over Transwell culture. 
  • Model neuroinflammation: Reproduce key features of neuroinflammation with exposure to inflammatory stimuli (TNF-α) or oligomeric species (α-synuclein), including neuronal death, glial activation, proinflammatory cytokine secretion, and compromised blood-brain barrier function. 
  • Investigate the impact of microglia: Study the effect of microglia—a cell type not present in most cell models—on blood-brain barrier function and neuroinflammatory response. 
  • Evaluate drug effect: Study the efficacy of neuroprotective drug candidates to reduce neuroinflammatory damage.

About Emulate

Emulate Inc. is a privately held company that creates advanced in vitro models for understanding how diseases, medicines, chemicals, and foods affect human health. Our lab-ready Human Emulation System® includes three components: Zoë® Culture Module, Organ-Chips, and analytical software applications. The platform provides a window into the inner workings of human biology and disease—offering researchers a new technology designed to predict human response with greater precision and detail than conventional cell culture or animal-based experimental testing. Each of the Emulate proprietary Organ-Chip models—including the liver, intestine, and kidney—contains tiny hollow channels lined with tens of thousands of living human cells and tissues and is approximately the size of an AA battery. An Organ-Chip is a living, microengineered environment that recreates the natural physiology and mechanical forces that cells experience within the human body. Our founding team pioneered the Organs-on-Chips technology at the Wyss Institute for Biologically Inspired Engineering at Harvard University. Emulate holds the worldwide exclusive license from Harvard University to a robust and broad intellectual property portfolio for the Organs-on-Chips technology and related systems. For more information, please visit emulatebio.com.

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