Organ Model: Colorectal cancer
Application: Cancer
Highlights
This study used Organ-Chips to recreate patient-specific colorectal cancer tumors in a dynamic, gut-like environment. The chips revealed that cancers with Ras mutations produce excess GABA, which drives tumor invasion, and that blocking this pathway can reduce invasiveness. These insights link clinical trial data to a new therapeutic opportunity and highlight the power of Organ-Chips to uncover cancer mechanisms that traditional models miss.
Related Resources
A Patient-Derived Organ-on-Chip Platform to Model the Colorectal Tumor Microenvironment and Cancer Progression
In this webinar from Drug Discovery Day 2024, Carly Strelez, PhD, discusses her work using Organ-on-a-Chip technology to better understand colorectal cancer progression and transform approaches to personalized medicine.
Cancer-on-a-chip: Modeling Colorectal Cancer Progression
In this on-demand webinar, Shannon Mumenthaler, PhD, discusses recent advancements made through combining Organ-Chip models with high content imaging and mass spectrometry-based metabolomics to improve our understanding of microenvironmental contributions to colorectal cancer progression.
