Colorectal cancer (CRC) is one of the deadliest cancers worldwide with over 900,000 people dying from the disease each year (Siegel et al., 2021). In the United States, the 5-year survival rate for patients with metastatic CRC is less than 15% (Siegel et al., 2020). To address this dismal outcome, there is an urgent need to better understand and ultimately control aspects of cancer progression.
In a recent paper published in iScience, researchers from the Lawrence J Ellison Institute for Transformative Medicine describe an in vitro Organ-Chip model that emulates in vivo tissue structure and the tumor microenvironment (TME) to better understand intravasation, an early step in metastasis.
In this on-demand webinar, Dr. Mumenthaler discusses recent advancements made through combining Organ-Chip models with high content imaging and mass spectrometry-based metabolomics to improve our understanding of microenvironmental contributions to colorectal cancer progression.
Study results that will be discussed:
- Development and characterization of CRC-on-chip
- Metabolic comparison of Intestine Chips versus CRC chips
- Examination of tumor cell intravasation
- CRC cells exhibit phenotypic heterogeneity during intravasation
- Mechanical and biochemical cues from the TME impact CRC invasion