Organ Model: Lung (airway)
Application: Methodology development
Highlights
The authors developed new methods to process and analyze Emulate Organ-Chips by trimming and paraffin-embedding Chip-S1 consumables, which enabled routine histology, immunohistochemistry, and in situ hybridization on chip cross-sections. They also applied electron microscopy workflows to assess ultrastructural features, allowing identification of cell types and organelles and localization of marker proteins. Using these approaches, they compared Airway Lung-Chips and Colon Intestine-Chips to other culture formats, showing how chips influenced differentiation trajectories and cellular composition relative to primary tissue.
