Organ Model: Bone (Breast cancer metastasis)
Applications: Cancer
Highlights
Researchers recreated the osteolytic bone metastatic niche by co-culturing osteocytes, osteoclasts, and breast cancer cells in an Organ-Chip system. Multi-omics analyses—including RNA sequencing, cytokine profiling, and imaging—showed that the full tri-culture recapitulated in vivo biology, revealed synergistic pro-metastatic signaling, and aligned closely with gene expression profiles from gold-standard mouse models. These results validate this Organ-Chip model of osteolytic bone mestastasis as a scalable, human-relevant alternative to animal models and highlight its potential as a medium-throughput platform for uncovering therapeutic targets and screening drug candidates.
