Organ Model: Liver
Application: Toxicology
Highlights
Researchers used the Emulate Liver-Chip S1 Quad-Culture BioKit containing primary human hepatocytes, endothelial cells, stellate cells, and Kupffer cells to model radiation-induced liver disease (RILD). Radiation exposure on the chip reproduced key features of RILD—including DNA damage, cellular senescence, metabolic and endothelial dysfunction, inflammation, and stellate cell activation—and enabled discovery of molecular pathways involved. The chip was further used to test N-acetylcysteine amide (NACA), which reduced radiation-associated damage and supported identification of potential biomarkers for radiation response and treatment efficacy.
