Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract

Organ Model: Liver

Application: Toxicology

How Organ-Chips Were Used: The Liver-Chip S1 Quad-Culture was used to investigate cannabidiol-rich cannabis extracts-induced hepatotoxicity and pharmacological properties demonstrated in animal models. The users found found that while therapeutic doses were generally safe, higher concentrations disrupted antioxidant pathways and triggered mild liver injury. 

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