Organ Model: Liver
Application: Toxicology
Highlights
In this study, researchers used the Emulate Quad-Culture Liver-Chip to evaluate the hepatotoxicity of four phytocannabinoids—CBD, CBN, CBC, and CBG—by continuously dosing chips for 7 days and assessing markers of liver injury. The Liver-Chip revealed compound-specific toxicity profiles, with CBC showing the most pronounced hepatotoxic effects, and provided mechanistic insights into oxidative stress and mitochondrial dysfunction in both hepatocytes and non-parenchymal cells. These findings highlight the Liver-Chip as a human-relevant alternative for liver toxicity screening of cannabinoids.
