Establishing the Human Duodenum Chip as a Surrogate for Effective Human Permeability: In Vitro and In Silico Assessment

Organ Model: Intestine (Duodenum)

Applications: ADME

Highlights

Researchers used the Duodenum Intestine-Chip to enable more physiologically relevant measurements of drug permeability than conventional static or animal-based models. By benchmarking permeability of three model compounds against RRCK cells and correlating chip-derived values with clinical P_eff, the researchers demonstrated that Organ-Chip data can be integrated into PBPK platforms like Simcyp® and GastroPlus™ to improve predictions of human systemic exposure. This work highlights the potential of Organ-Chips to enhance drug absorption modeling and reduce reliance on less predictive preclinical systems.

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