Developing an RNA Signature for Radiation Injury Using a Human Liver-on-a-Chip Model

Organ Model: Liver

Application: Toxicology

How Organ-Chips Were Used: Here, users demonstrated the potential utility of a human Liver-Chip to model organ-specific radiation injury, providing a platform for the development of radiation medical countermeasure and for biomarker validation. Users also identified biomarkers of RILI and defined cell-specific targets for potential radiation mitigation therapies.

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