Organ Model: Liver
Application: Toxicology
Highlights
The FDA used the Emulate Liver-Chip S1 to culture primary human hepatocytes and non-parenchymal liver cells under continuous perfusion, enabling extended drug exposure and collection of effluent for biomarker analysis. By identifying optimized ELISA- and chemistry-based methods, the study established standardized, reproducible approaches for measuring translational liver injury biomarkers in Organ-Chips, supporting their use in predictive toxicology and regulatory science.
