Organ Model: Lung (airway)
Application: ADME
Highlights
In pursuit of a more reliable method for predicting the permeability of inhaled compounds during the development of new and generic drugs, the authors in this study used a small airway Lung-Chip to recapitulate the pulmonary air-liquid interface (ALI) with primary epithelial and vascular endothelial cell layers. This study showed that the small airway Lung-Chip recapitulated relevant cell types and many morphological features in the lung. The apparent permeabilities measured indicated that albuterol sulfate and formoterol fumarate would be categorized as highly permeable, while olodaterol HCl would be categorized as a low permeable drug.
