Organ Model: Brain
Applications: Neuroscience
Highlights
This work covers several key components of establishing a functional brain-on-a-chip model to create a controlled environment that simulates the brain’s extracellular matrix and vasculature. These include incorporating various cell types, such as astrocytes, endothelial cells, pericytes, and immune cells, as well as the use of human-induced pluripotent stem cells (iPSCs) to derive these cell types, procedures to establish a functional multicultural system to study cell–cell interactions within the neurovascular unit, and methods to evaluate the model’s functionality through imaging techniques and biochemical assays.
