Under the terms of the collaboration agreement with Janssen, Emulate will provide its Organs-on-Chips technology to advance the clinical goals for three research programs: the use of the Lung-on-Chip and Thrombosis-on-Chip to evaluate pulmonary thrombosis; use of the Liver-on-Chip to better predict liver toxicity, a major cause of drug failures in the clinic; and a third undisclosed research program. Emulate will obtain rights to any discoveries related to the Organs-on-Chips platform that result from the research collaboration. Janssen has the option to extend the collaboration beyond the initial three programs, to include additional organs, disease models or drug programs. Other terms of the agreement are not disclosed.
“With Janssen as a preeminent leader in the pharmaceutical industry and Emulate’s advanced Organs-on-Chips technology, we aim to transform the R&D paradigm for drug development to better predict how humans will respond to drug candidates. We expect that this will improve the overall effectiveness of drug development processes and ultimately, lead to increased success rates for the advancement of better and safer drug candidates,” said Hamilton.
Emulate is commercializing the Organs-on-Chips technology that is based on pioneering work conducted by Donald Ingber, M.D., Ph.D. and his team at the Wyss Institute for Biologically Inspired Engineering at Harvard University. Emulate was launched from the Wyss Institute’s technology translation program in July 2014, providing Emulate with a worldwide license to a robust and broad intellectual property portfolio from Harvard University for the Organs-on-Chips technology.
Organs-on-Chips for Emulating Human Biology
Based on our Organs-on-Chips technology, which places living human cells in microengineered environments, Emulate has developed an integrated system that provides a window into the inner-workings of the human body. Our living products set a new standard for predicting human response, with greater precision and detail than today’s cell culture or animal-based testing. Emulate’s Organs-on-Chips contain tiny hollow channels lined by living human cells and tissues cultured under continuous fluid flow and mechanical forces, such as cyclic breathing and peristalsis, which recreate the microenvironment experienced by cells within the human body. Each Organ-on-Chip can contain tens of thousands of cells and is approximately the size of a USB memory stick. Organs-on-Chips are miniaturized living systems that represent the smallest functional unit of an organ that effectively recapitulate organ-level physiology and disease responses. Multiple Organs-on-Chips, such as lung, liver, intestine, kidney, skin, eye, and blood-brain-barrier, can be linked together by flowing human blood or nutrient-containing liquid to create a “Human-Body-on-Chips” that closely replicates whole body-level responses.
Emulate, Inc. is a private company that creates living products for understanding how diseases, medicines, chemicals, and foods affect human health. By setting a new standard for recreating true-to-life human biology, Emulate is advancing product innovation, design and safety across a range of applications in drug development, personalized health, agriculture, cosmetics and chemical-based consumer products. Emulate continues to develop a wide range of Organs-on-Chips, disease models and diagnostics through collaborations with industry partners and internal programs. By combining our Organs-on-Chips system with individuals’ stem cells, Emulate is accelerating progress toward a new era of precision medicine and personalized health. For more information, visit www.emulatebio.com.
The Yates Network