In the pharmaceutical industry, there is a need for more human-relevant preclinical models that can enable a mechanistic understanding of human diseases and drug action. Organs-on-Chips can help address this need by recreating in vivo-relevant function and key disease phenotypes in a more physiological microenvironment than conventional cell-based models.
In this webinar, we highlight how Organs-on-Chips technology can be applied across drug development to improve translation to the clinic. Geraldine Hamilton, Emulate co-founder, reviews:
- Challenges in drug development and why there is a need for more predictive models
- How the Liver-Chip can be applied to evaluate mechanistic toxicity
- How organoids and Organ-Chips can work together to create a more human-relevant Intestine model
- How to use our Human Emulation System to conduct Organ-Chip studies
Emulate Inc. is a privately held company that creates advanced in vitro models for understanding how diseases, medicines, chemicals, and foods affect human health. Our lab-ready Human Emulation System® includes three components: Zoë® Culture Module, Organ-Chips, and analytical software applications. The platform provides a window into the inner workings of human biology and disease—offering researchers a new technology designed to predict human response with greater precision and detail than conventional cell culture or animal-based experimental testing. Each of the Emulate proprietary Organ-Chip models—including the liver, intestine, and kidney—contains tiny hollow channels lined with tens of thousands of living human cells and tissues and is approximately the size of an AA battery. An Organ-Chip is a living, microengineered environment that recreates the natural physiology and mechanical forces that cells experience within the human body. Our founding team pioneered the Organs-on-Chips technology at the Wyss Institute for Biologically Inspired Engineering at Harvard University. Emulate holds the worldwide exclusive license from Harvard University to a robust and broad intellectual property portfolio for the Organs-on-Chips technology and related systems. For more information, please visit emulatebio.com.