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Evaluating the Kidney-Chip for Transporter-Mediated Drug-Drug Interactions Applications

October 21, 2020
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Synopsis

In this on-demand webinar, Covance and Emulate present promising new data on the characterization of the Kidney-Chip as a model to study and predict potential drug-drug interactions.

A More Human-Relevant Model
In the pharmaceutical industry, there is a need for more human-relevant preclinical models that can enable a mechanistic understanding of human diseases and drug action.
Organs-on-Chips can help address this need by recreating in vivo-relevant function and key disease phenotypes in a more physiological microenvironment than conventional cell-based models. Covance and Emulate are collaborating to evaluate the Proximal Tubule Kidney-Chip to study transporter-mediated DDIs to fill the gap between current in vitro options and clinical trials.

In this webinar, scientists from Emulate and Covance showcase promising new data on characterization of the Kidney-Chip as a model to study and predict potential drug-drug interactions.

 

About Emulate

Emulate Inc. is a privately held company that creates advanced in vitro models for understanding how diseases, medicines, chemicals, and foods affect human health. Our lab-ready Human Emulation System® includes three components: Zoë® Culture Module, Organ-Chips, and analytical software applications. The platform provides a window into the inner workings of human biology and disease—offering researchers a new technology designed to predict human response with greater precision and detail than conventional cell culture or animal-based experimental testing. Each of the Emulate proprietary Organ-Chip models—including the liver, intestine, and kidney—contains tiny hollow channels lined with tens of thousands of living human cells and tissues and is approximately the size of an AA battery. An Organ-Chip is a living, microengineered environment that recreates the natural physiology and mechanical forces that cells experience within the human body. Our founding team pioneered the Organs-on-Chips technology at the Wyss Institute for Biologically Inspired Engineering at Harvard University. Emulate holds the worldwide exclusive license from Harvard University to a robust and broad intellectual property portfolio for the Organs-on-Chips technology and related systems. For more information, please visit emulatebio.com.

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