organ-Chip Consumable

Chip-R1™ Rigid Chip

Improve precision in ADME and toxicology applications with a low-drug-absorption profile

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Overview

Dose your samples without concern for drug absorption

The Chip-R1 Rigid Chip is constructed with minimally drug-absorbing plastics, making it well suited for ADME and toxicology applications.

Key Benefits

Low Drug Absorption

The minimally drug absorptive properties of Chip-R1’s rigid plastic make it better suited for ADME and toxicology applications, where being able to accurately calculate drug recovery is critical.

Increased Shear Stress

With up to 2.3 dyn/cm2 of shear stress, Chip-R1 increases physiological relevance for applications such as immune cell recruitment.

Simplified Workflows

Chip-R1 features a pre-activated membrane, which streamlines the user workflow and saves time.

Shorter Working Distance for Imaging

Imaging workflows are easier due to the significantly shorter working distance required to reach the epithelial channel.

Diagram of Chip-R1
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Overview Video

Get to Know Chip-R1

Learn how Chip-R1 enables users to model organs without concern for drug absorption.

Case study

Improving the detection of hepatoxicity in drug dosing studies

Chip-R1 demonstrates a low-drug-absorbing profile for a panel of eight compounds with a range of physiochemical properties. Three of those compounds, including Nefazodone, are highly lipophilic compounds known to have high PDMS absorption liability. The Emulate Liver Quad Culture model on Chip-R1 was used to profile Nefazodone response in comparison to Chip-S1. Chip-R1 was able to detect a DILI response to Nefazodone that was absent on Chip-S1.

Absorption Profile of Hepatic-Relevant Compounds

Average Compound Recovery Between 24–28 Hours of Flow.
Recovery refers to ratio of outlet to inlet concentration of concerned compound. Data shown as mean ± SD. Significance in recovery determined by two-way ANOVA with Fisher’s LSD multiple comparison test. n=3–4 chips per condition, with values for top and bottom channels averaged per chip, **p<0.01, ****p<0.0001.

Albumin Response

Detecting DILI with Highly Absorbing Compounds – Albumin Response: Dosing with 30 µM Nefazodone on Chip-R1 at 30 µL/h caused a significant decrease in albumin secretion compared to Vehicle at all timepoints, while there is no hepatotoxic response when 30 µM Nefazodone is dosed on Chip-S1 at the same flow rate. Asterisks represent significance level compared to 0 µM control of respective chip type.

ALT Response

Detecting DILI with Highly Absorbing Compounds – ALT Response: Dosing with 30 µM Nefazodone on Chip-R1 at 30 µL/h induced severe hepatotoxicity and a significant increase in ALT secretion compared to Vehicle on Days 3 and 7, while there was no hepatotoxic response when 30 µM Nefazodone was dosed on Chip-S1 at the same flow rate.
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Part of the Human Emulation System®

The Human Emulation System is comprised of instruments, consumables, and software in a flexible, open format. The user-friendly platform gives researchers a window into the inner workings of human biology.

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FEATURED RESOURCE

Chip-R1 Basic Research Kit Data Sheet

Learn more about Chip-R1 and how it ensures greater accuracy for evaluating drug candidates, while building on key microfluidic capabilities.

View Data Sheet

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