GUIDED model
Bone Marrow-Chip
Understand bone marrow pathophysiology induced by drugs, radiation, or genetic mutations
Model Overview
Recapitulate the complexity of human bone marrow in vitro
Vascularization and media flow in Organ-Chips support the differentiation and maturation of multiple blood cell lineages over four weeks while improving CD34+ cell maintenance for more accurate recapitulation of bone marrow injury.
Benefits
Enhanced Cellular Differentiation
A four-week culture period supports erythroid differentiation as well as myeloid development and mobilization
Predict Toxic Response
The Bone Marrow-Chip recapitulates the toxic responses of human bone marrow to clinically relevant concentrations of known toxic agents
Model Radiation-Induced Injury
The Bone Marrow-Chip has been shown to appropriately model radiation-induced decreases in all cell types
Model Patient-Specific Pathophysiology
Researchers have demonstrated the ability to captured key hematological abnormalities associated with Shwachman-Diamond Syndrome
The Bone Marrow-Chip is a Guided Model that Emulate has firsthand experience developing and supporting. It can be created using a Basic Research Kit and a user’s own cell sources. For Guided Models, Emulate offers guidelines and field scientist support for building a Bone Marrow-Chip using the Human Emulation System.
Community Publication
On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology
Read this publication to learn how researchers from the Wyss Institute created a vascularized human Bone Marrow-Chip that recapitulates aspects of bone marrow injury and recovery after drug-induced myelosuppression.
Model Overview
Enhanced Cellular Differentiation
Prediction of Toxic Response
Radiation-Induced Injury
Disease Modeling
Part of the Human Emulation System®
The Human Emulation System is comprised of instruments, consumables, and software in a flexible, open format. The user-friendly platform gives researchers a window into the inner workings of human biology.
