Organ Model: Intestine (Caco-2)
Applications: Immunology & Inflammation
Highlights
In this study, a human Gut-on-a-Chip was used to model gastrointestinal acute radiation syndrome (GI-ARS). Researchers exposed intestinal epithelial cells and/or the surrounding culture medium to gamma radiation, enabling them to distinguish the direct effects of radiation from indirect injury mediated by irradiated extracellular factors. The Gut-on-a-Chip revealed that prolonged exposure to irradiated medium drove oxidative stress, epithelial injury, and disruption of intestinal tissue architecture. Using this model, the authors demonstrated that a commercially available probiotic formulation reduced oxidative stress, protected epithelial structure, and preserved tissue integrity, supporting its potential as a medical countermeasure for radiation-induced intestinal injury.
