Evaluation of the utility of the Beta Human Liver Emulation System (BHLES) for CFSAN’s regulatory toxicology program

Organ Model: Liver

Applications: Toxicology

Highlights

  • Liver-Chip accurately predicted toxicity with most chemicals.
  • Liver-Chip platform had high sensitivity and specificity, low variability, and high power.
  • Liver-Chips and 24 well plates exhibited similar toxicity with many compounds.
  • Flow of media or addition of LSECs may aid in slower toxicity seen in Liver-Chips.

Products Used In This Publication

Package design for the Chip-S1 Basic Research Kit
Chip-S1 Basic Research Kit
Render of the Emulate Human Emulation System on a white background, with the Zoë Culture Module in the front and the Orb Hub Module behind.
Zoë-CM2 Culture Module

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