Organ Model: Liver
Applications: Toxicology
Highlights
- In a single Liver-Chip, about 2100 z stack images were acquired in about 10 min encompassing the length of the Liver-Chip.
- Nuclei quantification suggests about 35–40k hepatocytes attach to Liver-Chip platform during seeding.
- Benzbromarone toxicity is easily and reliably quantified with large imaging data acquisition and automated quantification.
- Benzbromarone decreased mitochondrial function, increased apoptosis, and altered nuclear quantification in Liver-Chips.
