Organ Model: Spinal cord (ALS)
Application: Neurodegeneration
Highlights
In this study, researchers used Organ-Chips—specifically spinal cord chips (SC-chips)—to model young-onset, sporadic ALS by combining patient-derived iPSC motor neurons with brain endothelial-like cells. The microfluidic flow in the SC-chips enhanced motor neuron maturation and health, enabling the emergence of distinct neuronal subpopulations. Analyses revealed ALS-specific disruptions in glutamatergic and synaptic signaling, supporting the model’s relevance for studying disease mechanisms and its potential for future drug screening.
