Version 1.0 (Release Date: November 2021)
Introduction
The Apparent Permeability (Papp) Calculator is an Excel-based tool that helps users calculate the permeability of the epithelial-endothelial barrier in Emulate Organ-Chips. The Papp of a molecule is determined by dosing the inlet of one channel, collecting the effluent of both channels, and calculating the amount of compound that crossed through the membrane over time. This tool can be used to help researchers streamline the process of assessing the barrier function of healthy or diseased tissues, as well as studying drug transport.
Related information:
- Product Pages: Colon Intestine-Chip, Duodenum Intestine-Chip, Proximal Tubule Kidney-Chip
- Protocols: Barrier Function Analysis
- Technical Note: Characterization of the Colon Intestine-Chip