Overview
Learn how our Brain-Chip R1 can be applied to emulate the complex functions and physiology of the human neurovascular unit.
In this technical note, we review how the Brain-Chip R1 provides a reproducible, resting-state NVU model suitable for studies of BBB transport, permeability, and neuroinflammatory mechanisms.
Key highlights:
- Incorporates five iPSC-derived cell types, including proprietary BMECs that exhibit a physiologically relevant brain microvascular endothelial–like phenotype
- Maintains resting-state glia and a tight, stable barrier throughout a four-day experimental window
- Features a streamlined, 12-day direct-to-chip workflow with no pre-plating or expansion steps, enabling robust and reproducible performance
- Built on the Chip-R1™ Rigid Chip, which minimizes drug absorption to support reliable BBB transport studies