The Brain-Chip R1 is an isogenic, human-relevant Organ-Chip model designed to recapitulate the cellular diversity and functional interactions of the neurovascular unit (NVU). This model integrates five human iPSC-derived cell types—neurons, astrocytes, microglia, pericytes, and Emulate’s proprietary brain microvascular endothelial cells (BMECs)—within the dynamic, perfused microenvironment of the Chip-R1™ Rigid Chip.