Organ-Chip Applications

Organ-Chips for Drug Discovery & Development

In drug discovery and development, Organ-Chips from Emulate provide researchers with human relevant models that can be used to recreate complex disease biology, identify and validate druggable targets, evaluate drug candidate ADME properties, and gain a mechanistic understanding of human safety liabilities previously undetected by conventional preclinical models.

ADME-Tox

Evaluate small molecule ADME and mechanistic toxicity with clinically relevant results in drug discovery and development.

Cancer

Model tumor metastasis and immune system interaction in a more accurate tumor microenvironment to accelerate development of novel immuno-oncology therapies.

Cell Therapy

Model the holistic journey of CAR T-cell therapy for solid tumors—from vascular administration to target cell killing

Gene Therapy

Evaluate the potency and toxicity of gene therapy vectors

Immunology & Inflammation

Explore the contribution of the tissue-level inflammatory response and immune cell recruitment in the initiation and progression of disease.

Infectious Disease

Investigate mechanisms of human viral and bacterial infection, including SARS-CoV-2, and evaluate efficacy of candidate drugs to prevent or treat infection.

Microbiome

Gain mechanistic insights into microbe-host interaction and function in the complex intestine-specific microenvironment.

Neuroscience

Examine disease mechanisms and neuroinflammation, as well as evaluate the safety, efficacy, and blood-brain barrier penetration of novel therapeutics.