Synopsis
This upcoming webinar hosted by the APS Translational Physiology Interest Group featuring Passley Hargrove-Grimes, PhD, of the National Center for Advancing Translational Sciences (NCATS) will discuss the “Clinical Trials on a Chip” initiative and the utility of tissue chip technology to cross-validate disease model endpoints, establish recruitment criteria and stratify patient populations.
Gautam Mahajan, PhD, of Emulate, will introduce the core principles and mechanisms of organ-on-a-Chip technology and its applications to neuroscience research, including tissue interfaces, physiological flow and multicellular interactions to improve translational relevance beyond traditional static models. Mahajan will then present an in-depth overview of Emulate’s Brain-Chip R1, a first-in-class, isogenic five-cell iPSC model of the human neurovasculature.
Dmitriy Krepkiy, PhD, of NCATS, will showcase research from the Tissue Chips in Space program, which uses tissue chips on the International Space Station to study the effects of microgravity on the human body. The research focuses on how microgravity exerts a unique range of stresses and pathophysiological perturbations on human-derived cells and tissues.




