Synopsis
Join us for a webinar on October 10th at 10am EDT (7am PDT / 3pm BST / 4pm CEST), where Lisa Chakrabarti, PhD, from Institut Pasteur will explain how her team developed a lymphoid Organ-Chip (LO Chip) using the Emulate Chip-S1® Stretchable Chip to address the challenge of predicting vaccine immunogenicity in humans. Dr. Chakrabarti will describe how the LO chip recreated key lymphoid tissue features, including T cell/B cell interactions and emigration of matured plasmablasts, and demonstrated the capability to assess responses to mRNA vaccines.
Key highlights from this webinar include how:
- The model recreates lymphoid tissue features, including CD4+ T cell/B cell cluster formation and emigration of matured plasmablasts.
- The LO Chip effectively mimics vaccine boosts, amplifying SARS-CoV-2 Spike protein-specific B cells and antibody production.
- The dynamically perfused culture system outperforms traditional 2D and 3D static cultures in immune response simulation.
- The LO Chip is responsive to both protein and mRNA-encoded antigens, highlighting its potential for preclinical evaluation of vaccine boosting strategies.
