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International Society for Stem Cell Research 2021 (ISSCR)

June 21, 2021
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Synopsis

At this year’s ISSCR Annual Meeting, we are thrilled to sponsor and showcase our work at the Innovation Showcase in front of scientific leaders during this multi-day event. The ISSCR Annual Meeting brings together leaders in stem cell science and regenerative medicine from across the world to connect, collaborate, and discuss the latest advances in the field, new data, and the year’s most compelling breakthroughs.

 

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Agenda

June 2, 2021

1:00 pm  — 2:00 pm

Virtual

Iosif Pediaditakis, PhD

Microengineered Human Brain-Chip for Disease Modeling Applications

The need for human-relevant systems that can recreate key aspects of brain physiology and pathophysiology are being driven by the challenges of using the currently available animal models for translational research. An improved understanding of the neurovascular unit function and its alterations in disease should lead to new strategies for therapeutic intervention in neurological and neurodegenerative disorders. Here we present a human Brain-Chip system engineered to recapitulate critical aspects of the complex neurovascular unit. Our human organotypic microphysiological system includes endothelial cells, pericytes, glia, and neurons and maintains blood-brain barrier permeability at in vivo relevant levels. You will also hear from the Board of Governors Regenerative Medicine Institute on how they have created an induced pluripotent stem cell (iPSC) derived model of the human gut-brain axis and are beginning to use this platform to interrogate the contribution of various gut microbes and microbial metabolites in promoting CNS disease pathology. Progress in developing a blood-brain barrier (BBB)-Chip and an Intestine-Chip from iPSCs which recapitulate several in vivo molecular functions and can be fluidically linked to simulate the gut-brain axis will be presented.

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Speaker Spotlight

Ville Kujala

Associate Director of Research