The Chip-R1 Rigid Chip minimizes drug absorption while maintaining the essential architecture of Chip-S1. This enables researchers to build biologically complex Organ-Chip models for tissues that do not require stretch (e.g., liver, kidney, brain, and lung airway).
Here, we describe the development of the Chip-R1 Rigid Chip and the Liver-Chip R1 organ model, including data from an equivalency study that demonstrates its utility in modeling the liver and predicting drug hepatotoxicity.
- The Chip-R1™ Rigid Chip has the same two-channel configuration as the Chip-S1® Stretchable Chip, with several updates, including reduced drug absorption.
- The Liver-Chip R1 demonstrates robust liver functionality, as indicated by morphology, marker expression, albumin production, and drug metabolism.
- The Liver-Chip R1 displays increased sensitivity to detecting the drug-induced liver injury risk of small-molecule drugs with absorption liability in PDMS.
- The Chip-R1 exhibits reduced absorption of a range of small molecules with diverse physicochemical properties.