Altered Gut Microbiome and Immune Response in Crh-deficient Mice: A Novel Role for CRH in the Maintenance of Intestinal Homeostasis?

Background and Aims

Corticotropin Releasing Hormone (CRH), is the major mediator of the stress adaptive response in mammals and is implicated in the development and progress of intestinal inflammation. We have previously demonstrated that Crh-null (Crh-/-) mice are more susceptible to DSS- induced colitis, develop a more severe systemic disease and are unable to restitute the intestinal epithelial cell barrier, phenomena partially related to a defective regulation of autophagy. Our aim was to investigate the role of CRH in the host-microbiome interaction in the mouse intestine.