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The Future: You-on-a-Chip

June 1, 2015

By Chris Hinojosa Director of Discovery
By Chris Hinojosa Director of Discovery

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Concept for a real-time loop between patient, primary care, and a personalized biochip.

The Future: You-on-a-Chip

A bold new precision medicine research program

We are accelerating progress toward a new era of precision medicine. This is an emerging approach for disease treatment and prevention that takes into account the genes, environment, and lifestyle of each person.

With the potential for Organ-Chips personalized with your own living cells, we could transform the way each of us understands our own health and the way medicine is practiced.

 

“This will open up new ways for us to design truly personalized treatments based on each patient’s unique genetic profile using their own individualized chips.” — Shlomo Melmed, M.D., Senior Vice President for Academic Affairs and Dean of the Medical Faculty at Cedars-Sinai.

By combining our Organ-Chips with induced pluripotent stem cells (or iPS cells), we have the potential to open a new world of possibilities for precision medicine. iPS cells can be generated directly from adult cells and programmed to give rise to every other cell type in the body, such as neurons, heart, pancreatic, and liver cells. We can obtain iPS cells from an individual’s skin or blood and program them into different tissue types to create patient-specific Organ-Chips.

Our plans include creating individually tailored Organ-Chips with a patient’s own cells to allow biology to be predicted on a person-by-person basis. Imagine one day being able to use your own cells to create a personal Lung-Chip, your own Heart-Chip, or even your own “You-on-a-Chip.”