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DTSTAMP:20261109T080346
CREATED:20260921T200041Z
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UID:11575-1794481200-1794484800@emulatebio.com
SUMMARY:Modeling natural HIV infection\, immunopathogenesis\, and antiretroviral therapy in a Lymphoid Organ-Chip
DESCRIPTION:Secondary lymphoid organs play a central role in HIV infection\, serving as important sites of viral replication\, immune dysfunction\, and viral persistence. Yet\, studying these complex interactions in a physiologically relevant human system remains challenging. Conventional in vitro models often require artificial immune cell activation and can struggle to capture key features of the human immune response to HIV. \nIn this webinar\, Dr. Hongshuo Song from University of South Florida will share how she used Emulate Organ-on-a-Chip technology to create a Lymphoid Organ-Chip to model HIV infection in a dynamic\, human-relevant microenvironment. The model supports high-density human immune cells within a 3D extracellular matrix\, enabling researchers to investigate how HIV interacts with immune cells in conditions designed to more closely resemble human lymphoid tissue. \nDr. Song demonstrated that multiple HIV strains could productively replicate in the Lymphoid Organ-Chip without artificial T cell activation. The model also recapitulated several hallmarks of HIV immunopathogenesis\, including CD4 T cell depletion\, changes in the CD8/CD4 ratio\, and immune activation. When treated with antiretroviral therapy\, viral replication was rapidly suppressed\, further demonstrating the model’s potential for studying therapeutic response. \nTogether\, these findings highlight the potential of the Lymphoid Organ-Chip as a human-relevant platform for investigating HIV infection\, immunopathogenesis\, and viral persistence. The model may also provide new opportunities to study emerging therapies and strategies aimed at achieving long-term viral remission or a functional cure. \nKey Learning Points \n\nHow a human Lymphoid Organ-Chip can model HIV infection without the artificial T cell activation commonly required in conventional in vitro systems\nHow the model reproduces key features of HIV immunopathogenesis\, including CD4 T cell depletion and immune activation\nHow antiretroviral therapy affects HIV replication within the Lymphoid Organ-Chip\nHow this human-relevant model could support research into HIV persistence\, therapeutic response\, and future functional cure strategies
URL:https://emulatebio.com/event/modeling-natural-hiv-infection-in-a-lymphoid-organ-chip/
CATEGORIES:Webinar
ATTACH;FMTTYPE=image/png:https://emulatebio.com/wp-content/uploads/2026/09/Website-Webinar-Thumbnail-USF-HIV-Nov-2026.png
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DTSTART;VALUE=DATE:20261115
DTEND;VALUE=DATE:20261119
DTSTAMP:20261109T080346
CREATED:20261008T192315Z
LAST-MODIFIED:20261019T205708Z
UID:11630-1794700800-1795046399@emulatebio.com
SUMMARY:Society for Neuroscience 2026
DESCRIPTION:Meet Emulate at Society for Neuroscience 2026 — Booth #425 \nJoin Emulate at SfN2026\, taking place November 15–18 in Washington\, DC. \nVisit Booth #425 for live demonstrations of the AVA™ Emulation System and Zoë-CM2® Culture Module\, two Organ-Chip platforms that enable researchers to study complex human biology in physiologically relevant in vitro environments. \nModeling the complexity of the human brain remains a significant challenge in neuroscience research and drug development. Emulate’s Organ-on-a-Chip technology offers a powerful approach to recreating key features of the human neurovascular unit\, enabling researchers to investigate blood-brain barrier function\, neuroinflammation\, neurodegenerative diseases\, and CNS drug delivery. \nTogether\, AVA and Zoë provide flexible solutions for advancing human-relevant neuroscience research\, from exploratory disease modeling to more scalable\, automated drug development workflows. \nStop by Booth #425 to see the technology in action and learn how Emulate’s Organ-on-a-Chip platforms can help uncover new insights into human brain biology and accelerate the development of more effective CNS therapeutics. \nJoin Emulate and ZEISS for an Evening of Networking!\nWe’re also excited to partner with ZEISS Life Science Solutions to host a special networking reception during SfN2026! \nStep away from the conference floor and join fellow researchers for an evening of drinks\, light bites\, and engaging conversation. Whether you’re exploring new approaches to neuroscience research\, looking to connect with peers\, or simply unwinding after a busy day\, we hope you’ll join us for this informal gathering of the ZEISS and Emulate scientific communities. \nEvent Details \n\nDate: Sunday\, November 15\, 2026\nTime: 6:00–8:00 PM ET\nLocation: Dirty Habit DC – Glass House\, 555 8th Street NW\, Washington\, DC\n\nSpace is limited\, and advance RSVP is required. Attendance is by invitation.
URL:https://emulatebio.com/event/society-for-neuroscience-2026/
CATEGORIES:In Person
ATTACH;FMTTYPE=image/png:https://emulatebio.com/wp-content/uploads/2026/10/SfN-2026.png
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