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Predicting the Immunogenicity of Vaccines and Biotherapeutics Using a Human Lymphoid Organ-Chip Model

October 20, 2022
10:00 am — 11:00 am
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Synopsis

Vaccines and biotherapeutics are critical tools for protecting human health, particularly as our battle against the SARS-CoV-2 pandemic wages on and the need for variant-specific vaccines increases. To improve our ability to predict immune responses to vaccine candidates, Raphaël Jeger-Madiot of Institut Pasteur has developed a 3D in vitro model of a human lymphoid organ using the Emulate Chip S-1 Stretchable Chip. In this webinar on October 20th at 10:00 AM ET, Dr. Jeger-Madiot will discuss the development of the Lymphoid Organ-Chip (LO-Chip) model and how it can be used to predict the immunogenicity of vaccines and biotherapeutics, particularly for SARS-CoV-2 vaccines.

Key Points You Will Learn:

  • What the benefits of the LO-Chip model are compared to static 2D or 3D cultures.
  • How the LO-Chip can be used to evaluate recall responses to both protein & mRNA-based SARS-CoV-2 vaccines.
  • How the LO-Chip provides sensitive detection of memory B cell responses upon perfusion of the SARS-CoV-2 spike protein.
  • How to simultaneously detect CD4+ T cell and memory B cell activation in the LO-Chip.
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Speaker Spotlight

Raphaël Jeger-Madiot

Postdoctoral Fellow, Institut Pasteur